Oxadiazole

1,2,4-Oxadiazole





Reference:
J. Med. Chem. 2021, 64, 14142–14152.

Pyrazolopyridine

1H-Pyrazolo[4,3-c]pyridine





a.t.: ambient temperature
The second reaction was carried out under argon atmosphere (Ar atm.).

Reference:
J. Med. Chem. 2025, 68, 5097-5119.

Indole

1H-Indole

Reference:
J. Med. Chem. 2021, 64, 1, 417–429.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Pyrrolopyridine

2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol





Reference:
J. Med. Chem. 2021, 64, 1, 417–429.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Imidazopyridazine

Imidazo[1,2-b]pyridazine





Reference:
J. Med. Chem. 2025, 68, 21982-21916.

Pyrrolotriazole

6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole





Reference:
J. Med. Chem. 2025, 68, 23050-23077.

Triazolopyrimidinedione

[1,2,4]Triazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione





Reference:
Sci. Adv. 2021, 7, eabg4168.

Pyrimidinetrione

Pyrimidine-2,4,6(1H,3H,5H)-trione





Reference:
J. Med. Chem. 2025, 68, 21099-21119.

Cyclopropane

Reference:
Org. Lett. 2015, 17, 4944–4947.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

Reference:
Org. Lett. 2015, 17, 4944–4947.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

Triazole

Reference:
ACS Pharmacol. Transl. Sci. 2025, 8, 1072–1086.