4-Pyridone

Route 1

Reference:
Org. Process Res. Dev. 2016, 20, 1461-1468.

Route 2

Reference:
Org. Lett. 2015, 17, 564-567.

The pyridones illustrated in the Routes 1 and 2 are key intermediates used to synthesize dolutegravir and cabotegravir, HIV integrase inhibitors.