Dihydropyrimidinethione

3,4-Dihydropyrimidine-2(1H)-thione





Reference:
J. Med. Chem. 2025, 68, 24869–24889.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

1,4-Dihydropyrimidine

Reference:
J. Med. Chem. 2025, 68, 24869–24889.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Imidazole

1H-Imidazole





Reference:
J. Med. Chem. 2025, 68, 25844-25865.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Imidazopteridinone

Imidazo[1,2-f]pteridin-6(5H)-one





Reference:
J. Med. Chem. 2025, 68, 25844-25865.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Oxadiazole

1,2,4-Oxadiazole





Reference:
J. Med. Chem. 2021, 64, 14142–14152.

Pyrazolopyridine

1H-Pyrazolo[4,3-c]pyridine





a.t.: ambient temperature
The second reaction was carried out under argon atmosphere (Ar atm.).

Reference:
J. Med. Chem. 2025, 68, 5097-5119.

Indole

1H-Indole

Reference:
J. Med. Chem. 2021, 64, 1, 417–429.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Pyrrolopyridine

2,3-Dihydro-1H-pyrrolo[2,3-b]pyridin-3-ol





Reference:
J. Med. Chem. 2021, 64, 1, 417–429.

The detailed experimental procedures can be found in the freely accessible Supporting Information.

Imidazopyridazine

Imidazo[1,2-b]pyridazine





Reference:
J. Med. Chem. 2025, 68, 21982-21916.

Pyrrolotriazole

6,7-Dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole





Reference:
J. Med. Chem. 2025, 68, 23050-23077.

Triazolopyrimidinedione

[1,2,4]Triazolo[1,5-a]pyrimidine-5,7(4H,6H)-dione





Reference:
Sci. Adv. 2021, 7, eabg4168.

Pyrimidinetrione

Pyrimidine-2,4,6(1H,3H,5H)-trione





Reference:
J. Med. Chem. 2025, 68, 21099-21119.

Cyclopropane

Reference:
Org. Lett. 2015, 17, 4944–4947.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

Reference:
Org. Lett. 2015, 17, 4944–4947.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

Triazole

Reference:
ACS Pharmacol. Transl. Sci. 2025, 8, 1072–1086.

Triazolopyrimidine

Triazolo[4,5-d]pyrimidine




Reference:
ACS Pharmacol. Transl. Sci. 2025, 8, 1072–1086.

Azauracil

Reference:
J. Med. Chem. 2014, 57, 3912-3923.
The detailed experimental procedures can be found in the freely accessible Supporting Information.

Pyridazinone

Pyridazin-4(1H)-one





Reference:
J. Med. Chem. 2014, 57, 22, 9627-9643.

Benzoimidazopyrimidine

1,4-Dihydrobenzo[4,5]imidazo[1,2-a]pyrimidine

Reference:
J. Med. Chem. 2023, 66, 890-912.

Imidazopyridine

Imidazo[1,2-a]pyridine
Groebke–Blackburn–Bienaymé Multicomponent Reaction





Reference:
Monatsh Chem 2008, 139, 931-933.

4-Pyrone

Reference:
Org. Lett. 2007, 9, 2517-2520.